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More powerful logrank permutation tests for two-sample survival data

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Weighted logrank tests are a popular tool for analysing right-censored survival data from two independent samples. Each of these tests is optimal against a certain hazard alternative, for example, the… Click to show full abstract

Weighted logrank tests are a popular tool for analysing right-censored survival data from two independent samples. Each of these tests is optimal against a certain hazard alternative, for example, the classical logrank test for proportional hazards. But which weight function should be used in practical applications? We address this question by a flexible combination idea leading to a testing procedure with broader power. Besides the test's asymptotic exactness and consistency, its power behaviour under local alternatives is derived. All theoretical properties can be transferred to a permutation version of the test, which is even finitely exact under exchangeability and showed a better finite sample performance in our simulation study. The procedure is illustrated in a real data example.

Keywords: logrank permutation; powerful logrank; permutation; tests two; permutation tests; survival data

Journal Title: Journal of Statistical Computation and Simulation
Year Published: 2018

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