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Abstract Two new copper(II) complexes, [CuL(HL)]·ClO4 (1) and [Cu2Br2L2]·0.85H2O (2), where L is the monoanionic form of 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL), have been prepared. The complexes were characterized by infrared and UV–vis… Click to show full abstract
Abstract Two new copper(II) complexes, [CuL(HL)]·ClO4 (1) and [Cu2Br2L2]·0.85H2O (2), where L is the monoanionic form of 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL), have been prepared. The complexes were characterized by infrared and UV–vis spectra, and single crystal X-ray diffraction. Complex 1 is a mononuclear copper(II) species and 2 is a bromido-bridged dinuclear copper(II) species. The Cu ion in 1 is in an octahedral coordination mode and that in 2 is trigonal-bipyramidal. The Jack bean urease inhibitory assay indicated that 2 is active, with IC50 value of 20.6 ± 2.3 μmol L−1, while 1 is inactive. Molecular docking of 2 with Jack bean urease was studied.
Journal Title: Journal of Coordination Chemistry
Year Published: 2017
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