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Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes

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Abstract A series of symmetrical and nonsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag2O to afford their corresponding mononuclear Ag(I)-NHC complexes. These… Click to show full abstract

Abstract A series of symmetrical and nonsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag2O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques and analyzed by DFT/TDDFT and docking methods. Also, the structures of 2a and 2e were determined by single-crystal X-ray crystallography. These new Ag–NHC complexes were screened for their antibacterial activities against Gram-positive, Gram-negative bacteria, fungi, and nosocomial agents.

Keywords: analysis benzimidazole; benzimidazole ylidene; theoretical analysis; properties theoretical; synthesis antimicrobial; antimicrobial properties

Journal Title: Journal of Coordination Chemistry
Year Published: 2020

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