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Post hysterectomy occurrence of endometrial adenocarcinoma in association with granulosa cell tumour: a case report

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Hyperestrogenism is a strong risk factor for endometrial adenocarcinoma. Granulosa cell tumours cause high oestrogen levels. In patients with granulosa cell tumours, endometrial pathologies associated with hyperestrogenism ranging from endometrial… Click to show full abstract

Hyperestrogenism is a strong risk factor for endometrial adenocarcinoma. Granulosa cell tumours cause high oestrogen levels. In patients with granulosa cell tumours, endometrial pathologies associated with hyperestrogenism ranging from endometrial hyperplasia to carcinoma are encountered quite commonly (Ottolina et al. 2015). Endometrial tissues, either original or ectopic, are sensitive to hyperestrogenism. In patients with endometriosis who have had a total abdominal hysterectomy and salpingooophorectomy, unopposed oestrogens may cause malignant changes in any remaining endometrial deposits (Zanetta et al. 2000). Here, we report a case with a pelvic mass consisting of endometrial adenocarcinoma cells occurring 20 years after a total abdominal hysterectomy and left salpingo-oophorectomy, and 19 months after the excision of a granulosa cell tumour followed by chemotherapy.

Keywords: cell tumour; granulosa cell; cell; endometrial adenocarcinoma

Journal Title: Journal of Obstetrics and Gynaecology
Year Published: 2017

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