LAUSR

Giant condylomata acuminata, or a Buschke–L€ owenstein tumour, was first described by Abraham Buschke and Ludwig L€ owenstein in 1925 on the penis of a male patient. Their observations and histopathologic results led them to conclude that they were dealing with an exuberantly growing condyloma with normal maturation of the epithelium, no cellular atypia, with no clearly cancerous and destructive potential (Steffen 2006). To-date, the disease hallmark of this particular tumour is characterised by the development and slow progression of exophytic, ulcerative and cauliflower-shaped tumours that infiltrate in the adjacent tissue. Histologically, the basement membrane involvement is the main difference between a Buschke–L€ owenstein tumour and a squamous-cell carcinoma (Spinu et al. 2014). The disease is considered to be sexually transmitted, as human papillomavirus (HPV) types 6 and 11 are the most common found causative factors. The well-known risk factors are: smoking, multiple sexual relations, anaerobic infections, local chronic inflammation and immune deficiency (Martin et al. 2008; Spinu et al. 2014).