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Ovarian Leydig cell tumour diagnosis in a postmenopausal woman with uterine bleeding: a case report and literature review

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Leydig cell tumours are a rare subgroup of steroid cell tumours, accounting for approximately 0.1% of all ovarian tumours. These usually produce androgens and cause virilisation with signs of hirsutism,… Click to show full abstract

Leydig cell tumours are a rare subgroup of steroid cell tumours, accounting for approximately 0.1% of all ovarian tumours. These usually produce androgens and cause virilisation with signs of hirsutism, temporal balding, polycythaemia, and endometrial atrophy (Boehnisch et al. 2019). Here, we present a case of a rare Leydig cell tumour with postmenopausal uterine bleeding due to oestrogenic effect and polycythaemia due to androgenic effect. Although the initial consultation was for postmenopausal uterine bleeding, additional screening revealed polycythaemia and virilisation leading to the diagnosis of an ovarian tumour. Additionally, we found improvement in polycythaemia after the surgical removal of the ovarian Leydig cell tumour.

Keywords: cell; cell tumour; uterine bleeding; postmenopausal; leydig cell

Journal Title: Journal of Obstetrics and Gynaecology
Year Published: 2022

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