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ABSTRACT Red propolis is a well-known potent antimicrobial source because of its various bioactive compounds. This work aims to submit a sample of Brazilian red propolis to supercritical CO2 extraction,… Click to show full abstract
ABSTRACT Red propolis is a well-known potent antimicrobial source because of its various bioactive compounds. This work aims to submit a sample of Brazilian red propolis to supercritical CO2 extraction, with subsequent chemical characterisation by HPLC and UHPLC–MS, and to evaluate the antifungal activity against three strains of Candida glabrata. The method proved to be selective for the extraction of benzophenones. The results demonstrated a correlation between the presence of benzophenones and antifungal activity. The supercritical extract that seems to be the richest in benzophenones was the one obtained with a pressure of 300 bar and was the most active against the C. glabrata strains. Abbreviations: SFE, Supercritical Fluid Extraction; MIC, Minimal Inhibitory Concentration; SC, Supercritical; BZP, benzophenones
Journal Title: Separation Science and Technology
Year Published: 2018
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