LAUSR

Abstract Infectious disease outbreaks have occurred many times in the past decades and are more likely to occur in the future. Recently, Büyüktahtakin et al. (2018) proposed a new epidemics-logistics model to control the 2014 Ebola outbreak in West Africa. Considering that different diseases have dissimilar diffusion dynamics and can cause different public health emergencies, we modify the proposed model by changing capacity constraint, and then apply it to control the 2009 H1N1 outbreak in China. We formulate the problem to be a mixed-integer non-linear programming model (MINLP) and simultaneously determine when to open the new isolated wards and when to close the unused isolated wards. The test results reveal that our model could provide effective suggestions for controlling the H1N1 outbreak, including the appropriate capacity setting and the minimum budget required with different intervention start times.