LAUSR

ABSTRACT Objective: Although bispectral index (BIS) has been widely used for predicting neurological outcomes in clinical practice, its optimal value concerning maximum (BISmax), minimum (BISmin) and mean (BISmean) on accurately predicting the prognosis of patients with hypoxic-ischemic encephalopathy (HIE) after resuscitation has not been clearly determined. Methods: For a total number of 45 cases, the duration of each BIS measurement was 12 h, with the data collected at a 30 min interval. Outcome was recorded as survival and non-survival count 60 days after the resuscitation. Receiver operator characteristic curve was used to assess the BISmax, BISmin and BISmean for predicting clinical outcome. Results: By the end of observation, 20 cases (44.4%) survived with a significantly higher BISmax. The area under the curve for BISmax of predicting survival was the highest compared to BISmin and BISmean. The optimal cut-off value of BISmax was 71.5 with 100% sensitivity and 60% specificity. Ten patients presented BIS value down to zero at any time point did not survive the observation. Conclusion: The BISmax is a better outcome predictor than BISmin or BISmean for patients with HIE after resuscitation. Lower BISmax represents higher risk of mortality. Additionally, BIS value decreases to zero represents a poor outcome.