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Comparative Analysis of Outcomes and Clinicopathological Characteristics of Duodenal Adenocarcinoma: A SEER Analysis

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Abstract Duodenal adenocarcinoma is an uncommon, malignant tumor usually accompanied by a poor prognosis. We identified 3150 duodenal adenocarcinoma cases from the SEER database (1988–2013) to analyze clinical characteristics and… Click to show full abstract

Abstract Duodenal adenocarcinoma is an uncommon, malignant tumor usually accompanied by a poor prognosis. We identified 3150 duodenal adenocarcinoma cases from the SEER database (1988–2013) to analyze clinical characteristics and outcomes. The Kaplan–Meier method was used to evaluate cancer-specific survival (CSS). Cox regression analysis was used to explore the prognostic factors of CSS. Adverse prognostic factors include higher tumor grade, later stage, tumor size ≥ 2cm, positive regional lymph nodes, and not undergoing surgical resection. Our results suggest, surgery is the optimal treatment for duodenal cancer, and combined radiotherapy does not improve survival.

Keywords: comparative analysis; outcomes clinicopathological; analysis; analysis outcomes; clinicopathological characteristics; duodenal adenocarcinoma

Journal Title: Cancer Investigation
Year Published: 2020

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