Photo by impulsq from unsplash
In this study, we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is… Click to show full abstract
In this study, we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by simulations, provides an adequate explanation of triazavirine’s mechanism of action as it pertains to SI peptide fibril formation.
Keywords:
supramolecular complexes;
triazavirine;
triazavirine supramolecular;
complexes modifiers;
structure;
modifiers peptide
Journal Title: Journal of Biomolecular Structure and Dynamics
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Journal of Biomolecular Structure and Dynamics
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!