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Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABAAR)

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Propanidid is an intravenous anesthetic with transient action and rapid recovery features, but it is clinically unacceptable due to its side effects. AZD-3043, an analog of propanidid with the methoxy… Click to show full abstract

Propanidid is an intravenous anesthetic with transient action and rapid recovery features, but it is clinically unacceptable due to its side effects. AZD-3043, an analog of propanidid with the methoxy group substituted by the ethoxy group, has become the focus of recent development efforts. Although propanidid and AZD-3043 are known to act by potentiating the γ-aminobutyric acid type A receptors (GABAARs), their action sites and binding modes in the recognition of target proteins still remain unclear. In this study, molecular docking and ONIOM calculations were performed to explore the possible binding sites and binding modes of propanidid and AZD-3043 with the GABAAR. The predicted active region located in the transmembrane domain (TMD) of GABAAR was identified as the most favorable binding site for propanidid and AZD-3043, with the highest docking score (−39.69 and −39.44 kcal/mol, respectively) and the largest binding energy (−88.478 and −78.439 kcal/mol, respectively). The important role of amino acids Asp245, Asp424, Asp425, Arg428, Phe307, and Ser308 in determining the binding modes of propanidid or AZD-3043 with GABAAR was revealed. The detailed molecular interactions between propanidid and AZD-3043 and the GABAAR were revealed for the first time. This could improve our understanding of the action mechanism of general anesthetics and will be helpful for the design of more potential lead-like molecules.

Keywords: propanidid azd; acid type; possible binding; azd 3043; gabaar; aminobutyric acid

Journal Title: Journal of Biomolecular Structure and Dynamics
Year Published: 2018

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