LAUSR

A 67-year-old female presented with severe pain and blurred vision in the right eye that had persisted for one month. Her medical history included colon-carcinoma and skin-melanoma treated with a Trametinib and Dabrafenib for 12 months before ocular presentation. On examination, visual acuity was R: 6/12 and L: 6/9. The anterior-chamber was infiltrated with cells and amorphousmaterial (Figure 1A). Rubeosis of the iris (Figure 1B) and vitreous haemorrhage and fibrin with no pigmented cells were observed. On gonioscopy, amorphous material was observed in the inferior-angle (Figure 1C). The patient underwent a diagnostic vitrectomy. On cytology examination, atypical cells were observed with eccentric, irregular nuclei, with a prominent nucleolus and a moderate amount of cytoplasm. On Melen-A staining, the atypical cells showed cytoplasmic positivity for Melan-A (Figure 1D,E). The patient was treated with an immune checkpoint inhibitor. Secondary glaucoma and cataract developed due to the massive cancer cell infiltration; however, full resolution of the ocular infiltration was achieved (Figure 1F). At the end of follow-up, visual acuity was R: hand motion and L: 6/9.