LAUSR

ABSTRACT Hendra virus and Nipah virus (NiV) are highly pathogenic zoonotic paramyxoviruses, from henipavirus genus, that have emerged in late 1990s in Australia and South-East Asia, respectively. Since their initial identification, numerous outbreaks have been reported, affecting both domestic animals and humans, and multiple rounds of person-to-person NiV transmission were observed. Widely distributed fruit bats from Pteropodidae family were found to be henipavirus natural reservoir. Numerous studies have reported henipavirus seropositivity in pteropid bats, including bats in Africa, thus expanding notably the geographic distribution of these viruses. Interestingly, henipavirus infection in bats seems to be asymptomatic, in contrast to severe disease induced in numerous other mammals. Unique among the mammals by their ability to fly, these intriguing animals are natural reservoir for many other emerging and remerging viruses highly pathogenic for humans. This feature, combined with absence of clinical symptoms, has attracted the interest of scientific community to virus-bat interactions. Therefore, several bat genomes were sequenced and particularities of the bat immune system have been intensively analyzed during the last decade to understand their coexistence with viruses in the absence of disease. The peculiarities in inflammasome activation, a constitutive expression of interferon alpha, and some differences in adaptive immunity have been recently reported in fruit bats. Studies on virus-bat interactions have thus emerged as an exciting novel area of research that should shed new light on the mechanisms that regulate viral infection and may allow development of novel therapeutic approaches to control this highly lethal emerging infectious disease in humans.