LAUSR

Congenital leukemia is an extremely rare disorder that is diagnosed within the first 28 days of birth.1 Common clinical features of congenital leukemia include prominent hepatosplenomegaly and a high incidence of skin involvement. A distinctive feature of this condition is occurrence of spontaneous remission (SR) in some cases. Congenital leukemia is more commonly of myeloid than lymphoid origin and the optimal treatment strategy remains unclear. Significant chemotherapy-related toxicity has been observed in congenital leukemia.2 We report a case of congenital acute myeloid leukemia (AML) with t(9;11)(p12.3;q23.3);KMT2A-MLLT3. Transient spontaneous regression was observed for 5 weeks and an increased size of residual skin lesions was observed. We administered chemotherapy and induced complete remission without any severe adverse effects. We monitored disease activity so that we could initiate chemotherapy when the tumor burden was maximally debulked and aimed to reduce the toxicity of chemotherapy by delaying the induction of chemotherapy.