LAUSR

Abstract Purpose/Aim of the study: Patients referred for suspected colorectal cancer typically undergo whole large bowel investigation (WLBI) as per national guidelines. Sole change in bowel habit (CIBH) with no anemia/abdominal mass at time of referral has low oncological yield following diagnostic investigations, particularly for tumors proximal to the splenic flexure. Study aims were to evaluate cancer yield of patients referred for suspected colorectal cancer presenting with sole-symptom CIBH and to assess clinical and financial feasibility of a straight-to-test flexible sigmoidoscopy (FS). Materials and methods: We analyzed all 2-week wait referrals with sole CIBH between January 2013 and 2015. Information collected included cancer yield and oncological management. Results: Overall 1831 patient referrals were made during our study time. 719 (39.3%; median age 72 years, interquartile range: 65–79.5) were identified with sole CIBH at referral and underwent subsequent WLBI. 597 (83%) patients reported predominant looser/increased frequency stool (PLS) whilst the remaining 122 (17%) had predominant hard/decreased frequency stool (PHS). Overall, 18 were diagnosed with colorectal cancer (2.5%) with a further 9 patients (1.3%) harboring non-colorectal malignancies. The PHS group yielded a significantly higher proportion of colorectal cancers than the PLS group (adjusted OR 3.24, 95% CI: 1.23–8.54; p = .02). Colonic tumors proximal to the splenic flexure are uncommon in patients with sole CIBH (0.69%). In those with PLS, one proximal malignancy (0.17%) was detected with WLBI. Conclusions: Sole CIBH without anemia/abdominal mass yields a 2.5% colorectal malignancy rate from 2-week wait referrals. Those with PLS had a 0.17% yield of proximal tumors. A straight-to-test FS in this low risk group would be clinically effective with potential annual savings of more than £50 000.