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Blastic Plasmacytoid Dendritic Cell Neoplasm Following Acquired Erythropoietic Protoporphyria

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A 56-year-old Texas rancher with a prior diagnosis of acquired erythropoietic protoporphyria secondary to an underlying myelodysplastic disorder developed an uncommon tumor, blastic plasmacytoid dendritic cell neoplasm (BPDCN). During his… Click to show full abstract

A 56-year-old Texas rancher with a prior diagnosis of acquired erythropoietic protoporphyria secondary to an underlying myelodysplastic disorder developed an uncommon tumor, blastic plasmacytoid dendritic cell neoplasm (BPDCN). During his initial disease, analysis revealed a TET2 mutation, which is the most common mutation associated with BPDCN. This article discusses this unusual hema-topoietic neoplasm, the possible evolution from erythropoietic protoporphyria, and the underlying myelodysplastic process.

Keywords: erythropoietic protoporphyria; blastic plasmacytoid; acquired erythropoietic; plasmacytoid dendritic; cell neoplasm; dendritic cell

Journal Title: Baylor University Medical Center Proceedings
Year Published: 2017

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