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Unsuspected primary malignancy in the setting of elevated serum alpha-fetoprotein

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Abstract Hepatocellular carcinoma is the most common solid liver cancer and is screened for with serum alpha-fetoprotein (AFP) in patients with chronic hepatitis or cirrhosis. However, other tumors can produce… Click to show full abstract

Abstract Hepatocellular carcinoma is the most common solid liver cancer and is screened for with serum alpha-fetoprotein (AFP) in patients with chronic hepatitis or cirrhosis. However, other tumors can produce AFP, and one of these is the “hepatoid” adenocarcinoma, arising in extrahepatic sites. We present a patient with chronic hepatitis C, multiple liver tumors, and a marked elevation in AFP who was mistakenly thought to have hepatocellular carcinoma, but primary hepatoid adenocarcinoma arising at the gastroesophageal junction was discovered at autopsy.

Keywords: primary malignancy; alpha fetoprotein; unsuspected primary; serum alpha

Journal Title: Baylor University Medical Center Proceedings
Year Published: 2019

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