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Central nervous system intravascular lymphoma leading to rapidly progressive dementia

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Abstract Intravascular lymphoma is an uncommon subtype of B-cell lymphoma with neoplastic cells limited to the lumen of small blood vessels. We report a case of a 52-year-old man who… Click to show full abstract

Abstract Intravascular lymphoma is an uncommon subtype of B-cell lymphoma with neoplastic cells limited to the lumen of small blood vessels. We report a case of a 52-year-old man who presented with constitutional symptoms and rapidly progressive dementia. He was found to have diffuse leptomeningeal and faint parenchymal enhancement on magnetic resonance imaging and was subsequently diagnosed with intravascular lymphoma following a brain biopsy. He responded remarkably well to systemic and intrathecal chemotherapy. The diagnosis and treatment of intravascular lymphoma have been guided by a few case reports and are largely based on expert opinion.

Keywords: lymphoma; intravascular lymphoma; rapidly progressive; nervous system; central nervous; progressive dementia

Journal Title: Baylor University Medical Center Proceedings
Year Published: 2021

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