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Nodular Necrotizing-Scleritis Associated with Epstein-Barr Virus Infection: A Case Report

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ABSTRACT Purpose To report a case of necrotizing scleritis associated with Epstein-Barr virus (EBV) infection. Case report A 68-year-old woman with a history of scleral ulcer, perforation, and scleral graft,… Click to show full abstract

ABSTRACT Purpose To report a case of necrotizing scleritis associated with Epstein-Barr virus (EBV) infection. Case report A 68-year-old woman with a history of scleral ulcer, perforation, and scleral graft, with initial negative studies for infectious processes and autoimmune systemic-diseases consulted our service for a second opinion after 2 years of treatment without improvement. She presented severe conjunctival and scleral hyperemia, vascular tortuosity in 360°, areas of scleral thinning and an elevated lesion of nodular appearance. EBV serologic antibody IgG titers were strongly positive and IgM titers were borderline. A scleral biopsy showed granulation tissue with severe inflammation without the presence of tumor cells; PCR was positive for EBV. The patient was treated with antiviral therapy with resolution of the scleritis. Conclusions EBV although rare, should be considered as a differential diagnosis in patients with necrotizing scleritis with no improvement to conventional therapy.

Keywords: scleritis associated; scleritis; case; report; associated epstein; necrotizing scleritis

Journal Title: Ocular Immunology and Inflammation
Year Published: 2019

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