Abstract It is established that arterial stiffness is one of the risk factors for cardiovascular morbidity and mortality. We tested the hypothesis that alterations in genetic structure of circadian gene… Click to show full abstract
Abstract It is established that arterial stiffness is one of the risk factors for cardiovascular morbidity and mortality. We tested the hypothesis that alterations in genetic structure of circadian gene PER3 could affect hemodynamic parameters. Previously, we showed that CLOCK gene variants had a pronounced effect on arterial vasculature. Augmentation index (AIx) was significantly higher in the PER35/5 group than in the PER34/4 and PER34/5 groups, whereas other hemodynamic parameters, such as RWTT, PWV, and ASI, were not significantly different.
Journal Title: Biological Rhythm Research
Year Published: 2017
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