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Abstract The biotransformation of mulin-11,13-dien-20-oic acid (1), a diterpene isolated from extracts of Azorella compacta was evaluated using Aspergillus alliaceus UI 315 and Mucor circinelloides ATCC 7941. Cultures of A.… Click to show full abstract
Abstract The biotransformation of mulin-11,13-dien-20-oic acid (1), a diterpene isolated from extracts of Azorella compacta was evaluated using Aspergillus alliaceus UI 315 and Mucor circinelloides ATCC 7941. Cultures of A. alliaceus containing 1 produced the known metabolite 16-hydroxy-mulin-11,13-dien-20-oic acid (2) in 19.5% yield; alternatively, biotransformation of 1 by cultures of M. circinelloides produced two new metabolites identified as mulin-11,13-dien-16,20-dioic acid (3) and 7α,13β-dihydroxy-mulin-11-en-20-oic acid (4) on the basis of their spectroscopic data.
Journal Title: Biocatalysis and Biotransformation
Year Published: 2019
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