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Abstract A series of paclitaxel analogs modified at C-3′-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by 1H-NMR, 13C-NMR, HR-MS. Compound 7e exhibited potent… Click to show full abstract
Abstract A series of paclitaxel analogs modified at C-3′-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by 1H-NMR, 13C-NMR, HR-MS. Compound 7e exhibited potent ability to decrease TNFα (tumor necrosis factor α) in the LPS-activated RAW264.7 murine macrophage-like cell line. The preliminary data indicated that the anti-inflammatory effects may be related to MD-2 and Toll-like receptor 4 (TLR4), rather than Toll-like receptor 2 (TLR2).
Keywords:
anti inflammatory;
inflammatory evaluation;
evaluation novel;
synthesis anti;
paclitaxel analogs
Journal Title: Journal of Asian Natural Products Research
Year Published: 2017
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Journal Title: Journal of Asian Natural Products Research
Year Published: 2017
Link to full text (if available)
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recommendations!