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Three new benzolactones from Lavandula angustifolia and their bioactivities

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Abstract Three new benzolactones (1–3), together with four known ones (4–7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic… Click to show full abstract

Abstract Three new benzolactones (1–3), together with four known ones (4–7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1–3 showed obvious anti-TMV activities with inhibition rates of 26.9, 30.2, and 28.4%, which were at the same grade as positive control. Compounds 1–3 also showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 32.1–7.6 μM.

Keywords: benzolactones lavandula; new benzolactones; three new; lavandula angustifolia; angustifolia bioactivities

Journal Title: Journal of Asian Natural Products Research
Year Published: 2017

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