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Antibacterial flavonoids from the fruits of Macaranga hurifolia

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Abstract As part of our search for new secondary metabolites from Macaranga hurifolia Beille, a phytochemical investigation was carried out on the fruits that led to the isolation and characterization… Click to show full abstract

Abstract As part of our search for new secondary metabolites from Macaranga hurifolia Beille, a phytochemical investigation was carried out on the fruits that led to the isolation and characterization of two new prenylated flavonol derivatives named macafolias A (1) and B (2), along with five known compounds. Their chemical structures were established on the basis of extensive analysis of their 1–D and 2–D NMR (1H, 13C, APT, COSY, HSQC and HMBC) in conjunction with mass spectroscopy and by comparison with data from the literature. The in vitro assay of the antibacterial potency of the crude extract, fractions and some pure compounds were evaluated against a wide range of bacteria strains. Graphical Abstract

Keywords: flavonoids fruits; fruits macaranga; spectroscopy; macaranga hurifolia; antibacterial flavonoids

Journal Title: Journal of Asian Natural Products Research
Year Published: 2022

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