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Combinatorial biosynthesis: playing chess with the metabolism

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Abstract Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some… Click to show full abstract

Abstract Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some changes in their structure and biosynthesis mechanism are necessary for their properties to be more suitable and also for their production to be profitable. The main and most useful method to achieve this goal is combinatorial biosynthesis. This technique uses the multi-unit essence of the secondary metabolites biosynthetic enzymes to make changes in their order, structure and also the organism that produces them. Graphical Abstract

Keywords: biosynthesis; biosynthesis playing; playing chess; chess metabolism; combinatorial biosynthesis

Journal Title: Journal of Asian Natural Products Research
Year Published: 2022

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