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An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature… Click to show full abstract
An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible ring-opening mechanism of 6,19-epoxy bridge in compound 7 was first proposed and the structures of intermediates were supported by the LC-MS analysis of the reaction mixture.
Keywords:
ring opening;
synthesis hydroxyprogesterone;
opening mechanism;
mechanism epoxy;
epoxy bridge
Journal Title: Journal of Asian natural products research
Year Published: 2022
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Journal Title: Journal of Asian natural products research
Year Published: 2022
Link to full text (if available)
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recommendations!