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Abstract This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the… Click to show full abstract
Abstract This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the presence of poly(4-vinylpyridine). All reactions are performed under mild conditions in high yields during short -reaction times. Simple procedure, use of green and nontoxic solvents, low cost, commercial availability and recyclability of the catalyst are the main advantages of this method.
Journal Title: Polycyclic Aromatic Compounds
Year Published: 2018
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