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comprehensive review article by Yamada et al. (2021) on a topic that is a matter of scientific debate for quite some years now: the human relevance of the mode of… Click to show full abstract
comprehensive review article by Yamada et al. (2021) on a topic that is a matter of scientific debate for quite some years now: the human relevance of the mode of action (MoA) for liver tumor formation by chemicals that are activators of the constitutive androstane receptor (CAR). Following a critical analysis of currently available data concerning this topic the authors conclude that this MoA is qualitatively not plausible for humans. Their conclusion is based on a pivotal species difference in hepatocellular proliferation (a key event in CAR-mediated rodent liver tumor formation), supported by negative epidemiology data for the archetypical CAR activator phenobarbital (PB). According to the authors
Journal Title: Critical Reviews in Toxicology
Year Published: 2022
Link to full text (if available)
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