LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Flexible parametric accelerated failure time model.

Photo by thinkmagically from unsplash

Accelerated Failure Time (AFT) models are viable alternatives to the Cox proportional hazard model, where failure times are explicitly modelled with respect to covariates. A major problem with parametric AFT… Click to show full abstract

Accelerated Failure Time (AFT) models are viable alternatives to the Cox proportional hazard model, where failure times are explicitly modelled with respect to covariates. A major problem with parametric AFT models in practice is that statistical distribution used there often have a limited range of shapes, which may be inadequate to cope with real-life data. This paper presents an AFT model algorithm involving generalised lambda distributions (GLD) using maximum likelihood estimation, by extending and adapting existing work on GLD regression model and estimation, which would enhance the capabilities of AFT models owing to the rich shapes of GLDs. The proposed method is demonstrated to achieve parameter consistency and is very robust against outliers. A real-life example demonstrating the use of GLD AFT models compared to more established methods such as semi-parametric models of Buckley James regression, Accelerated Failure Time GEE model and Cox proportional hazard model is also given.

Keywords: aft models; model; accelerated failure; failure; failure time

Journal Title: Journal of biopharmaceutical statistics
Year Published: 2021

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.