LAUSR

BACKGROUND Dropped head syndrome (DHS) is a relatively rare disease and its potential relationship with drug exposure has been postulated but is poorly understood. RESEARCH DESIGN AND METHODS This retrospective study evaluated the adverse event reports of DHS in the FAERS between January1, 2004, to March 31, 2021. Empirical Bayes Geometric Means (EBGM) and the lower 95% one-sided CI of EBGM were calculated to identify disproportionate reporting of DHS associated with drugs. In addition, published case reports were identified in the PubMed, Embase and Cochrane Library up to 5 August 2021. RESULTS There were one hundred and ninety-three reports of DHS in the FAERS, in which nervous system agents were most frequently reported, followed by antineoplastic and immunomodulating agents. Pramipexole, ropinirole, levodopa, pregabalin, rotigotine, cisplatin, imatinib and botulinum toxin showed disproportionality signal based each on more than 5 cases. Ten published DHS case reports were identified in the literature. CONCLUSION Our study provides a more explicit profile on the occurrences and characteristics of DHS associated with drugs by analyzing the FAERS data and indicates that exposure of certain drug showed disproportionality signal with the increased DHS risk, which suggests the importance of further clinical and observational investigations.