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Cytotoxicity of flavonoids and isoflavonoids from Crotalaria bracteata

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Abstract A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata.… Click to show full abstract

Abstract A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata. Their structures were elucidated by a combination of spectroscopic methods. Compound 2 showed cytotoxicity against MCF-7 with an IC50 value of 79.90 μM whereas 2 and 4 exhibited cytotoxicity against the NCI-H187 cell line with IC50 values of 71.57 and 95.47 μM, respectively.

Keywords: crotalaria bracteata; flavonoids isoflavonoids; isoflavonoids crotalaria; cytotoxicity flavonoids; cytotoxicity

Journal Title: Natural Product Research
Year Published: 2017

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