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Abstract During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation… Click to show full abstract
Abstract During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation of a new ergostane derivative, named 3β, 4β, 20S-trihydroxyergosta-5, 24(28)-dien-16-one (1), together with five known sterides (3β, 23S)-ergosta-5, 24(28)-diene-3, 23-diol (2), ergosta-5, 24(28)-diene-3β-diol (3), stigmast-5-ene-3β, 7α-diol (4), sitoindoside I (5) and stigmast-3β, 5α, 6β-triol (6). The structure of the new compound was elucidated using a combination of 1 D, 2 D NMR techniques and HR-EI-MS analyses. All the compounds were evaluated for cytotoxic activity against tumor cell line BEL-7402 by MTT method. Graphical Abstract
Journal Title: Natural Product Research
Year Published: 2020
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