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A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2-4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was… Click to show full abstract
A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2-4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds 1-4 were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound 1 significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC50 value of 8.22 µM.
Journal Title: Natural product research
Year Published: 2020
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