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Two new dammarane-type ginsenosides from Panax ginseng.

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Two new dammarane-type ginsenosides elucidated as 3-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl]-20(S)-protopanaxadiol, named Ginsenoside Rb6(2); (Z)-6-O-β-D-glucopyranosyl-dammar-20(22), 24-diene-3β, 6α, 12β-triol, named (20Z)-Ginsenoside Rh4 (4); along with five known ginsenosides(1, 3, 5, 6, 7) were isolated from… Click to show full abstract

Two new dammarane-type ginsenosides elucidated as 3-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl]-20(S)-protopanaxadiol, named Ginsenoside Rb6(2); (Z)-6-O-β-D-glucopyranosyl-dammar-20(22), 24-diene-3β, 6α, 12β-triol, named (20Z)-Ginsenoside Rh4 (4); along with five known ginsenosides(1, 3, 5, 6, 7) were isolated from the radix and rhizome of wild ginseng (Panax ginseng). The structures were determined by chemical and comprehensive spectroscopic analysis, including 1D, 2D NMR, HR-ESI-MS and hydrolysis reaction.

Keywords: dammarane type; glucopyranosyl; glucopyranosyl glucopyranosyl; type ginsenosides; two new; new dammarane

Journal Title: Natural product research
Year Published: 2021

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