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Three new 8,4'-type oxyneolignans from the seeds of Ziziphus jujuba mill and their antitumor studies.

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Ziziphus jujuba Mill. is a deciduous shrub, belonging to the Rhamnaceae family. Phytochemical investigation of Z. jujuba seeds showed the presence of three undescribed 8,4'-type oxyneolignans (1-3). Their structures were… Click to show full abstract

Ziziphus jujuba Mill. is a deciduous shrub, belonging to the Rhamnaceae family. Phytochemical investigation of Z. jujuba seeds showed the presence of three undescribed 8,4'-type oxyneolignans (1-3). Their structures were elucidated by comprehensive spectroscopic analyses. All isolated compounds were tested for antitumor activity against two human hepatoma cells (Hep3B and HepG2) and exhibited moderate cytotoxicity (IC50: 33.79-49.62 µM).

Keywords: ziziphus jujuba; jujuba mill; jujuba; type oxyneolignans

Journal Title: Natural product research
Year Published: 2022

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