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Abstract A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) was isolated from Calendula officinalis methanol extract. The structure of 1 was determined based on the analysis of NMR spectra and HRESIMS. It was… Click to show full abstract
Abstract A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) was isolated from Calendula officinalis methanol extract. The structure of 1 was determined based on the analysis of NMR spectra and HRESIMS. It was tested for antimicrobial and antiprotozoal activities. Compound 1 showed leishmanicidal activity against L. donovani amastigote with an IC50 of 16.4394 µM and IC90 of 28.9015 µM and a weak antitrypanosomal activity with an IC50 of 37.6136 µM. The cytotoxicity of 1 was evaluated using standard experimental procedures against THP1 cells and no cytotoxicity was observed indicating its selectivity and safety. Supplemental data for this article can be accessed here. Graphical Abstract
Journal Title: Natural Product Research
Year Published: 2022
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