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Concise synthesis of marine natural products smenodiol and (−)-pelorol

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Abstract A facile synthesis of marine natural product smenodiol has been achieved in 23.2% overall yield within 8 steps from readily available starting materials, which facilitates a concise synthesis of… Click to show full abstract

Abstract A facile synthesis of marine natural product smenodiol has been achieved in 23.2% overall yield within 8 steps from readily available starting materials, which facilitates a concise synthesis of the marine natural product (−)-pelorol by employing a TMSOTf-mediated Friedel-Crafts reaction with a methyl ester in the aryl as the key step. Graphical Abstract

Keywords: marine natural; pelorol; concise synthesis; natural product; synthesis marine

Journal Title: Natural Product Research
Year Published: 2022

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