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Two new cytotoxic tetralin derivatives from Panicum turgidum

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Abstract Two new tetralin compounds were isolated from the aerial parts of Panicum turgidum Forssk. Their structures were elucidated by comprehensive 1 D and 2 D NMR experiments as well as high… Click to show full abstract

Abstract Two new tetralin compounds were isolated from the aerial parts of Panicum turgidum Forssk. Their structures were elucidated by comprehensive 1 D and 2 D NMR experiments as well as high resolution ESI mass spectrometry. In addition, these two compounds have been tested for in vitro cytotoxicity against SKOV3 (Ovarian Carcinoma) and BT-549 (Breast Carcinoma). Compound 1 showed good cytotoxic activities against SKOV3 and BT 549 with IC50 value of 5.65 ± 0.31 and 10.3 ± 0.56 µg/mL, respectively Graphical Abstract

Keywords: tetralin derivatives; derivatives panicum; panicum turgidum; new cytotoxic; cytotoxic tetralin; two new

Journal Title: Natural Product Research
Year Published: 2022

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