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Euphorfinoids M and N (1 and 2), two previously undescribed ent-abietane diterpenoids, together with seven known analogues (3-9), were isolated from the roots of wild Euphorbia fischeriana. Their structures were… Click to show full abstract
Euphorfinoids M and N (1 and 2), two previously undescribed ent-abietane diterpenoids, together with seven known analogues (3-9), were isolated from the roots of wild Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, ECD, and comparison with structurally related known analogues. Bioassays against proliferative effects of HeLa cell line showed that compound 1 was the most active with IC50 3.62 ± 0.31 μM.
Keywords:
ent abietane;
antiproliferative ent;
abietane diterpenoids;
diterpenoids euphorbia;
euphorbia fischeriana
Journal Title: Natural product research
Year Published: 2023
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Journal Title: Natural product research
Year Published: 2023
Link to full text (if available)
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recommendations!