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One anti-tumour C21 steroidal glycoside from Cynanchum wallichii Wight.

The roots of Cynanchum wallichii Wight is rich in C21 steroidal glycosides according to previous research. In this study, a systematic chemical study was performed on the roots of C.… Click to show full abstract

The roots of Cynanchum wallichii Wight is rich in C21 steroidal glycosides according to previous research. In this study, a systematic chemical study was performed on the roots of C. wallichii, leading to the isolation of one previously undescribed C21 steroidal glycoside compound (1) and a known compound, gagamine (2). In vitro bioassay indicated that compound 1 showed a strong inhibitory effect on AGS cells, with the IC50 value 7.8 μM.

Keywords: wallichii wight; cynanchum wallichii; c21; c21 steroidal; steroidal glycoside

Journal Title: Natural product research
Year Published: 2025

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