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Persulfidation is the mechanism underlying sulfide-signaling of autophagy.

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In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells.… Click to show full abstract

In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.

Keywords: underlying sulfide; mechanism; persulfidation mechanism; sulfide signaling; mechanism underlying; autophagy persulfidation

Journal Title: Autophagy
Year Published: 2021

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