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The features of diphenhydramine poisoning are well described [1]. Although the elimination half-life of diphenhydramine has been calculated after therapeutic dose [2–6], it has not been estimated in overdose. We… Click to show full abstract
The features of diphenhydramine poisoning are well described [1]. Although the elimination half-life of diphenhydramine has been calculated after therapeutic dose [2–6], it has not been estimated in overdose. We report the clinical course, diphenhydramine concentrations and elimination half-lives in two patients after diphenhydramine overdose. Toxicological screening was performed using ultra-performance liquid chromatography (Waters ACQUITY; Waters, Co., Milford, MA) with tandem mass spectrometry (Waters TQD detector) and exact mass time of flight (Waters Xevo G2 QTof) and LC-MS/MS was employed to quantify drugs present.
Journal Title: Clinical Toxicology
Year Published: 2017
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