LAUSR

Abstract In this paper, miRNA expressions and their possible functions evaluated by using the qPCR, miRNA microarray and transcriptome in microcystins (MCs)-toxicity in fish, mammal and in vitro models were reviewed. In general, expressions of most miRNAs determined were altered in animal tissues or in vitro cells after MCs-exposure. Studies have also provided a pivotal understanding of miRNAs involved in the potential MCs-toxicity mechanism. These works suggest that further investigation, particularly in humans, is required to better understand the relationship between development of disease and MCs-exposure. Finally, the revealed miRNA pathways associated with MCs hepatotoxicity may provide therapeutic targets for a variety of human liver diseases.