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ABSTRACT A novel, simple and efficient synthetic protocol has been developed for the synthesis of a series of thiazolidine-4-one and 3H-thiazole derivatives via a one-pot four-component condensation-cyclization reaction of hydrazine… Click to show full abstract
ABSTRACT A novel, simple and efficient synthetic protocol has been developed for the synthesis of a series of thiazolidine-4-one and 3H-thiazole derivatives via a one-pot four-component condensation-cyclization reaction of hydrazine with allyl isothiocyanate and an α-haloketone in the presence of various aldehydes. This new protocol produces novel thiazolidine-4-one and 3H-thiazole derivatives in excellent yields. The remarkable features of this methodology are high yields, easy work-up and a one-pot simple reaction method. GRAPHICAL ABSTRACT
Journal Title: Journal of Sulfur Chemistry
Year Published: 2018
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