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Why have transgenic rodent models failed to successfully mimic Alzheimer’s disease. How can we develop effective drugs without them?

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Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CiberNed: Centro de Investigación en Red, enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain; Departamento… Click to show full abstract

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CiberNed: Centro de Investigación en Red, enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain; Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Asturias, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, Spain; Instituto de Salud del Principado de Asturias (ISPA), Asturias, Spain; Department of Biochemistry and Physiology, Faculty Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain

Keywords: biochemistry; asturias spain; models failed; failed successfully; rodent models; transgenic rodent

Journal Title: Expert Opinion on Drug Discovery
Year Published: 2019

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