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How can we improve the design of small molecules to target thioredoxin reductase for treating cancer?

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The ubiquitous thioredoxin reductase (TrxR, encoded by TXNRD gene) enzymes are essential to maintain the cellular redox homeostasis. The most outstanding function of TrxR is to keep its native subs... Click to show full abstract

The ubiquitous thioredoxin reductase (TrxR, encoded by TXNRD gene) enzymes are essential to maintain the cellular redox homeostasis. The most outstanding function of TrxR is to keep its native subs...

Keywords: thioredoxin reductase; improve design; reductase; design small; small molecules; molecules target

Journal Title: Expert Opinion on Drug Discovery
Year Published: 2020

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