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Cytomegalovirus induced hemophagocytic lymphohistiocytosis: diagnostic and treatment challenges for the future

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massive T-cell activations, causing a cytokine storm and macrophage activation. This consequently leads to hemophagocytosis and inflammatory tissue damage. Potential target points for pharmacological intervention include virus replication, T-cell proliferation,… Click to show full abstract

massive T-cell activations, causing a cytokine storm and macrophage activation. This consequently leads to hemophagocytosis and inflammatory tissue damage. Potential target points for pharmacological intervention include virus replication, T-cell proliferation, and general immune activation. Created with BioRender.

Keywords: lymphohistiocytosis diagnostic; diagnostic treatment; hemophagocytic lymphohistiocytosis; treatment challenges; induced hemophagocytic; cytomegalovirus induced

Journal Title: Expert Review of Hematology
Year Published: 2022

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