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Synthesis of functionalized 4H-Chromenes catalyzed by lipase immobilized on magnetic nanoparticles

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ABSTRACT In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5-triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via… Click to show full abstract

ABSTRACT In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5-triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via a multicomponent reaction firstly. Under the optimized reaction conditions, immobilized MML displayed high catalytic performance (Yield: 81–96%) and excellent reusability, indicating a high potential for practical operation. GRAPHICAL ABSTRACT

Keywords: chromenes catalyzed; synthesis functionalized; lipase immobilized; catalyzed lipase; functionalized chromenes

Journal Title: Green Chemistry Letters and Reviews
Year Published: 2018

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