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ABSTRACT The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to… Click to show full abstract
ABSTRACT The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side effects such as activation of regulatory T cells and vascular endothelium.
Keywords:
lymphocytes improved;
method cytokine;
cytotoxic lymphocytes;
improved method;
targeting cytotoxic
Journal Title: Oncoimmunology
Year Published: 2017
Link to full text (if available)
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Journal Title: Oncoimmunology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!